100% PURE GERMAN COLLAGEN HYDROLYSATE
Our collagen hydrolysate is extracted from bovine source using a multi-stage enzymatic extraction process; it is then purified, concentrated, sterilized and dried. This results in cold water soluble powder of collagen hydrolysate which make it highly bioavailable.
Hydrolyzed collagen is a special type of protein that is “pre-digested” or broken down into small peptide chains for enhanced absorption into the body. Several studies have demonstrated that hydrolyzed collagen peptides are quickly absorbed after ingestion and readily deposited in the body’s tissues – where they act as building blocks for new connective tissue and may help to trigger the body’s own internal collagen production.
Hydrolyzed collagen is a special type of protein that is “pre-digested” or broken down into small peptide chains for enhanced absorption into the body. Several studies have demonstrated that hydrolyzed collagen peptides are quickly absorbed after ingestion and readily deposited in the body’s tissues – where they act as building blocks for new connective tissue and may help to trigger the body’s own internal collagen production.
THE SCIENCE BEHIND OUR INGREDIENTS
Collagen is the most common protein in animals and Collagen types I, II, and III are the most common collagen in the humans. These collagens are known as fibrous collagen, because they form long strands. Altogether, collagen types I, II, and III are 80% to 90% of the collagen in people. Because they are structurally similar, the processes for producing collagen types I, II, and III are in tissues also are similar.
References:
1. Collagen: The Fibrous Proteins of the Matrix. National Center for Biotechnology Information
National Institute of Health (https://www.ncbi.nlm.nih.gov/books/NBK21582/)
1. Collagen: The Fibrous Proteins of the Matrix. National Center for Biotechnology Information
National Institute of Health (https://www.ncbi.nlm.nih.gov/books/NBK21582/)
COLLAGEN ROLE IN THE HUMAN BODY
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More than twenty kinds of collagen are found in the tissues of our body.
Collagen is to the tissues in the human body, what steel rods are to reinforce concrete. If the steel rods of the frame are weak, all the structure becomes weak. Collagen mainly serve as support, filler, joint, insulation, protection or transport in the case of the blood system. Without this conjunctive tissue matrix rich in collagen, which acts as “a sort of glue that keeps our body together,” we would be a puddle. |
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Aging and lifestyle directly affect several metabolic processes including our body’s ability to synthesize new proteins, including collagen.
According to the Nutrition and Food Science Centre of the University of McGill, it is mentioned that if our body is under stress, due to injuries or degenerative problems related to aging, it would need even more amino acids than it normally does. What happens if there is lack of collagen in the body? The decrease of collagen starts as at age 30 and can lead to:
Though the above is not a major health problem for a 30 year old, the reduction of collagen as we continue to age will have a direct effects on our health and life quality on the longer term. |
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RESEARCH DONE ON COLLAGEN HYDROLYSATE
There have been medical observations, key laboratory and clinical studies on the effect of collagen hydrolysate on joint health carried out over the past 20 years by international leading experts of different medical disciplines.
All clinical studies reveal positive effects of collagen hydrolysate on joint health, especially on osteoarthritis, for example:
In 1986, the beneficial effect of collagen hydrolysate on osteoarthritis was patented (European patent No 0254289 Agents for the treatment of osteoarthritis).
In spring 2003 Oesser et al published a laboratory study that could explain the potential basic mechanism of the clinical observations. Scientists were able to demonstrate, that collagen hydrolysate stimulates collagen synthesis in cartilage cells (chondrocytes).
All clinical studies reveal positive effects of collagen hydrolysate on joint health, especially on osteoarthritis, for example:
- significant reduction of pain
- reduced need for analgesics
- improvement of joint mobility
In 1986, the beneficial effect of collagen hydrolysate on osteoarthritis was patented (European patent No 0254289 Agents for the treatment of osteoarthritis).
In spring 2003 Oesser et al published a laboratory study that could explain the potential basic mechanism of the clinical observations. Scientists were able to demonstrate, that collagen hydrolysate stimulates collagen synthesis in cartilage cells (chondrocytes).
WHAT ARE THE MOST IMPORTANT STUDIES ON COLLAGEN HYDROLYSATE?
Dr Roland Moskowitz, Director of the Arthritis Research Institute, Cleveland/USA conducted an international study (USA; UK; Germany) with 390 patients suffering from osteoarthritis found a pain-relieving effect from collagen hydrolysate. The patients were able to significantly reduce their consumption of analgesics and reported an improvement in physical function. [2]
The most extensive research was carried out by Prof. Milan Adam, Professor of Rheumatology at the University of Prague, published a randomized, double-blind study that involved 81 osteoarthritis patients. Analysis of the results revealed that the pain score in the group treated with collagen hydrolysate dropped by more than 26 percent compared to the control group which led to the issue of a European patent, No 0254289 Agents for the treatment of osteoarthritis. [4]
Both studies reveal the positive effects of collagen hydrolysate on joint health, especially on Osteoarthritis.
The most extensive research was carried out by Prof. Milan Adam, Professor of Rheumatology at the University of Prague, published a randomized, double-blind study that involved 81 osteoarthritis patients. Analysis of the results revealed that the pain score in the group treated with collagen hydrolysate dropped by more than 26 percent compared to the control group which led to the issue of a European patent, No 0254289 Agents for the treatment of osteoarthritis. [4]
Both studies reveal the positive effects of collagen hydrolysate on joint health, especially on Osteoarthritis.
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Dr Steffen Oesser, physiologist at the University Of Kiel, Germany published key studies on cartilage metabolism and regeneration. [1] Oesser et al. demonstrated for the first time that collagen hydrolysate stimulates collagen synthesis in cartilage cells. [3] This latest demonstrates that Collagen Hydrolysate stimulates collagen synthesis in cartilage cells that will boost the formation of new cartilage tissue. |
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References:
1. Dr. Steffen Oesser, physiologist, University of Kiel, Germany in his publication, “Cell & Tissue Research 311:393-9; March 2003.
2. Moskowitz, R. (2000). "Role of collagen hydrolysate in bone and joint disease". Seminars in arthritis and rheumatism 30 (2): 87–99. doi:10.1053/sarh.2000.9622. PMID11071580
3. Oesser S et al (2007) Osteoarthritis Cartilage 15: C61-C62, 94
4.Ruiz-Benito, P.; Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza-Peralta, M.A., Vallejo-Flores, C.A., Vargas-Lopez, S.V., Villacis-Tamayo, R.A. and Zurita-Gavilanes, L.A. (2009). "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort". International journal of food science and nutrition 12: 1–15.
1. Dr. Steffen Oesser, physiologist, University of Kiel, Germany in his publication, “Cell & Tissue Research 311:393-9; March 2003.
2. Moskowitz, R. (2000). "Role of collagen hydrolysate in bone and joint disease". Seminars in arthritis and rheumatism 30 (2): 87–99. doi:10.1053/sarh.2000.9622. PMID11071580
3. Oesser S et al (2007) Osteoarthritis Cartilage 15: C61-C62, 94
4.Ruiz-Benito, P.; Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza-Peralta, M.A., Vallejo-Flores, C.A., Vargas-Lopez, S.V., Villacis-Tamayo, R.A. and Zurita-Gavilanes, L.A. (2009). "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort". International journal of food science and nutrition 12: 1–15.